Furthermore, FOXF1 expression is largely silenced in colorectal cancer cell lines with inactive p53, and knockdown of FOXF1 caused genomic instability in colorectal cancer cells with a defect in the p53-p21WAF1 checkpoint, suggesting that FOXF1 plays an essential role in colorectal tumorigenesis [20]. The gene discussed is TP53; the disease is colorectal cancer.