In addition, relevance of CDK9 mediated MCL-1 regulation and mechanism by which CDK9 regulates MCL-1 is not known in esophageal adenocarcinoma, even though CDK9 mediated MCL-1 regulation is one of commonest mechanism by which CDK9 inhibitors have shown anti-tumorogenic effects in other tumors [19, 20]. This evidence concerns the gene MCL1 and esophageal adenocarcinoma.