The difference in effects of type (stable vs. transient) of genetic downregulation of CDK9 on critical downstream targets of CDK9 (p-Pol II and MCL-1) is new and additional work with different types of genetic downregulation in esophageal adenocarcinoma and other solid tumor cell lines will provide more insights in understanding mechanism of action of CDK9 and identifying appropriate target for the CDK9 inhibition in esophageal adenocarcinoma. The gene discussed is CDK9; the disease is esophageal adenocarcinoma.