FUCA1 and colon adenocarcinoma: It must be pointed out, in this respect, that, even though α-L-fucosidase-1 is usually found as a soluble component of lysosomes, this enzyme was also found as a membrane fraction- associated in brain [46] and colon adenocarcinoma HT 29 cells [47] and as a plasma membrane-associated in rat spermatozoa [48, 49].