Increased expression of HIF-1α in tumor cells, whether induced by hypoxia or by aberrant oncogenic signaling, actively drives tumor growth and progression by regulating the expression of crucial target genes such as vascular endothelial growth factor (VEGF), carbonic anhydrase IX (CAIX) and glucose transporter 1 (Glut-1) [8, 10]. Here, CA9 is linked to neoplasm.