The prognostic value of HIF-1α in MTC is in line with findings in numerous studies performed in other cancer-types like; bladder -, breast -, cervical -, colorectal -, gastric -, head and neck -, non-small cell lung -, ovarian -, pancreatic -, prostate cancer and glioblastoma, glioma, melanoma, gastrointestinal stromal tumor and renal cell carcinoma. This evidence concerns the gene HIF1A and central nervous system cancer.