It is well established that multiple solid tumor types, including melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), thymoma, ovarian, and colorectal cancer, generate an immunosuppressive tumor microenvironment and avoid T cell-mediated cytolysis by expressing PD-L1 [10–12]. This evidence concerns the gene CD274 and renal cell carcinoma.