PLEKHO1 and osteoporosis: However, due to the deficiency of CKIP-1 in all cells in knockout mice and CKIP-1 was known to regulate macrophage proliferation, osteoporosis and many other processes, it is possible that CKIP-1 depletion in other cells other than hematopoietic cells participate the differentiation of megakaryocytes, which need to be further investigated.