PLEKHO1 and cardiac hypertrophy: Previous studies reported that the PH domain-containing protein CKIP-1 (casein kinase 2-interacting protein-1, also known as PLEKHO1) played a role in the regulation of macrophage homeostasis, tumorigenesis, cardiac hypertrophy as well as cell apoptosis, cell morphology, and the actin cytoskeleton [10–18].