Apparently, AMPK inhibitor CC significantly suppressed the thalidezine-induced autophagy and cell death in DLD-1 cells BAX-BAK DKO (Supplementary Figure 3B and Figure 6B), confirming the crucial role of AMPK signalling in thalidezine-autophagic cell death in apoptosis defective cancer cells. The gene discussed is BAK1; the disease is cancer.