Although two Raf inhibitors, sorafenib and PLX4720, were demonstrated to inhibit the growth of MDR-NIH 3T3 cells with different phosphorylation extent on AMPK, both of them inhibited mTOR and induced autophagy, suggesting the possible role of AMPK activation and Raf inhibition in abrogating the multidrug resistance of cancers [57]. The gene discussed is MTOR; the disease is cancer.