TP53 and lung cancer: Additionally, researches have discovered many signaling pathways which possess certain internal relations with the lung cancer, such as PI3K-AKT signaling pathway (Map 04151 in KEGG) [24–26], VEGF signaling pathway (Map 04370 in KEGG) [27–29], P53 signaling pathway (Map 05223 in KEGG) [30–32] and so on.