To determine whether the gene signatures modulated by NUSAP1 overexpression or knockdown in prostate cancer cell lines relate to the behavior of human prostate cancers, we used the Significance Analysis of Microarrays technique (SAM) [40] to identify genes positively and negatively correlated with NUSAP1 in a prostate cancer dataset with well annotated clinical follow-up [41]. Here, NUSAP1 is linked to Familial prostate cancer.