As shown in Supplementary Figure 3C and Table 1D, when the same amount of cells with control shRNA or CD73 shRNA planted to the right or left inguen of the same mouse, respectively, the amount of tumors formed by RCC cells with CD73 shRNA was less than those with control shRNA, and the maximal tumor size was smaller correspondingly, indicating that tumor formation of cells with reduced CD73 expression was notably suppressed. This evidence concerns the gene NT5E and renal cell carcinoma.