ADRB2 and hypertensive disorder: In addition, only one missense mutation was analyzed in the present study, and it is highly encouraged to incorporate more polymorphisms in close linkage disequilibrium with Trp64Arg polymorphism in ADRB3 gene and other adrenoreceptor genes, such as ADRB1 and ADRB2 genes, pending sufficient available publications to investigate their joint impact on blood pressure and hypertension risk.