ESR1 and neoplasm: No associations were found between DFNA5 CpG4 methylation and ischemia time, pathological tumor-node-metastasis (pTNM) staging, estrogen receptor (ER) status, progesterone receptor (PgR) status, lymphovascular invasion, tumor grade (Nottingham grading system), mitotic activity index (MAI) or maximal tumor diameter (Table 1).