We used vilazodone for these experiments because unlike some other SSRI vilazodone does not inhibit CYP2D6, which is required for the conversion of the breast cancer pro-drug tamoxifen into its active metabolite endoxifen, nor does it affect CYP3A4 activity, which metabolizes many chemotherapeutics [32]. The gene discussed is CYP2D6; the disease is breast cancer.