We determined the effect of the AZA and DAC hypomethylating agents on the release of sNKG2DL (MICA, MICB, ULBPs1-3) in two AML cell lines (KG1a and NB4) that showed high levels of these soluble molecules in their cellular supernatants at basal level. The gene discussed is MICA; the disease is acute myeloid leukemia.