The TIMP3 DNA methylation levels observed in healthy donors were highly homogeneous (median: 5 ± 1.2%, range 0 – 8.5%) whilst AML patients show highly variable methylation rates for TIMP3 (median: 8.8 ± 13.9%; range: 0–89%) (Figure 7A). Here, TIMP3 is linked to acute myeloid leukemia.