Importantly, in hypoxic conditions typical of tumour lesions, cancer cells upregulate the expression of disintegrin and metalloproteinase containing-domain 10 (ADAM10), which has been reported to cleave MICA/MICB from cell surface of prostate and breast cancer cell lines, thus contributing to impair NK cell-mediated tumour cell elimination (figure 1e) [57]. Here, MICB is linked to breast cancer.