Within the tumour microenvironment, M1 macrophages express high levels of IL-12 and low levels of IL-10 and are tumouricidal; on the other hand, M2 macrophages secrete high levels of IL-10 and low levels of IL-12, display poor antigen presenting capacity, and promote angiogenesis, tumour invasion and metastasis [112–114]. This evidence concerns the gene IL10 and neoplasm.