In mouse models of cancer, neutrophils have been shown to play a critical role in driving tumour cell dissemination and metastasis, acting as a bridge to facilitate interactions between cancer cells and metastatic sites; this process seems to be driven by ICAM-1 and CD44v, expressed on cancer cells and their molecular partners MAC-1 and L-selectin, respectively, expressed by neutrophils [17]. This evidence concerns the gene ICAM1 and cancer.