Additionally, by releasing a huge plethora of cytokines, including primarily IFNγ and IL4, followed by IL2, IL5, IL6, IL10, IL17, IL21, TNFα, TGFβ and GM-CSF [76], NKT cells are indirectly involved in inhibiting tumour angiogenesis [77] and enhancing antigen-specific immune responses, by the induction of dendritic cell maturation and B-cell activation (figure 1g) [78]. This evidence concerns the gene TGFB1 and neoplasm.