TAMs suppress anti-tumoural adaptive immunity acting on the intratumoural IL-10/IL-12 balance, critical for priming T-lymphocyte responses [117,118], and secreting an array of cytokines and chemokines involved in development and recruitment of immunosuppressive immune cells, such as Tregs, immature DCs and MDSCs (see below) [119]. This evidence concerns the gene IL10 and neoplasm.