They produce a variety of chemokines and cytokines, such as perforin–granzyme, tumour necrosis factor (TNF) and tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and IFN-γ [41–43], by which they are able to inhibit tumour growth and block angiogenesis. This evidence concerns the gene TNF and neoplasm.