ALAS2 and sideroblastic anemia: Congenital sideroblastic anemias are caused by defects in the early steps in heme synthesis, including those encoding the human homologs of yeast HEM25 (SLC25A38 in humans) and HEM1 (ALAS2 in humans) (Aivado et al. 2006; Boycott et al. 2013, 2014; Guernsey et al. 2009; Aoki et al. 1973; Cotter et al. 1992).