Several miRNAs were reported to inhibit different downstream genes to delay the progress of HCC, including miR-636 (inhibiting Ras-PI3K/AKT pathway) [40], miR-16 (inhibiting COX-2) [41], miR-497 (inhibiting CHEK1) [42], and so on. Here, CHEK1 is linked to hepatocellular carcinoma.