BRCA1 and neoplasm: Methylation levels ≥ 25% were only obtained for the promoters of APC in 44% (8/18), BRCA1 and CDKN2A in 11% (2/18) and ESR2 in 12% (2/17) of the tumor tissues and in addition for ESR2 in 6% (1/18) of the tumor-distant tissues.