In case of BRCA1 (r = 0.994, p < 0.001), exon 2 of CDKN2A (r = 0.651, p = 0.003) and ESR2 (r = 0.580, p = 0.015), methylation levels in tumor-adjacent tissues correlated with those in tumor-distant tissues. This evidence concerns the gene ESR2 and neoplasm.