In addition, p38-dependent inhibition of HMGB1 release was also demonstrated in cellular or animal models of severe acute pancreatitis and endotoxemia upon administration of the natural products glycyrrhizin, Dachengqi decoction, and the tetrahydroisoquinoline alkaloid THI-28 [36–38]. The gene discussed is HMGB1; the disease is acute pancreatitis.