These includes ectodermal dysplasia hair and nail type 4 (ECTD4; MIM 602032) lying on chromosome 12q13.13 with mutations in KRT85 gene [3], ectodermal dysplasia hair and nail type 5 (ECTD5; MIM 614927) located on chromosome 10q24.32-q25.1 [4], ectodermal dysplasia hair and nail type 6 (ECTD6; MIM 614928) with chromosomal address 17p12-q21.2 [5], ectodermal dysplasia hair and nail type 7 (ECTD7; MM 614929) lying on chromosome 12q13.13 with mutation in KRT74 gene [6] and ectodermal dysplasia hair and nail type 9 (ECTD9; MIM 614931) harboring HOXC13 gene on chromosome 12q13.13 [7–9]. The gene discussed is KRT85; the disease is pure hair and nail ectodermal dysplasia.