Tumor infiltrating PD-1-positive T-cells and tumoral expression of PD-L1 have been associated with poor prognosis in several tumors, including esophageal, pancreatic, gastric, hepatocellular, urothelial and renal cell carcinomas, follicular lymphoma, melanoma as well as soft tissue sarcomas [23–33]. This evidence concerns the gene CD274 and neoplasm.