We could efficiently block infection of fibroblasts by pre-incubating virions with PDGFR-α-Fc fusion protein and by pre-incubating cells with the PDGFR-α ligand PDGF-AA when virions were gO-positive, but not when gO was knocked out and infection was dependent on the pentameric gH/gL/UL128,130,131A complex [14,15]. The gene discussed is PDGFRA; the disease is infection.