PDGFRA and infection: Our findings very well fit prominent phenotypes found in cell culture for gH/gL-associated mutations, for example the strongly reduced infection of fibroblasts by mutants expressing less gO or lacking gO [14–16,19], the inability of laboratory strains, which have lost the ability to form the pentameric complex, to infect cell types with no or low levels of PDGFR-α [24,37], and the susceptibility of HCMV infection to cellular PDGFR-α levels [24,37,42,49,50].