The dominance of gH/gL/gO-driven entry in infections with supernatant virus suggests that the PDGFR-α—gH/gL/gO interaction may play a crucial role in horizontal infection with free virus from body fluids like urine or breast milk and thus be an interesting target for vaccines or antiviral drugs designed to prevent HCMV primary infection. This evidence concerns the gene PDGFRA and infection.