Other baseline characteristics significantly associated with an increased risk of mortality were increasing age, DM, cardiovascular disease (ischaemic heart disease [IHD]), cerebrovascular disease [CVD], peripheral vascular disease [PVD]), an age-adjusted CCI ≥5, higher SBP, increased PP, increasing cystatin C, lower eGFR, and higher serum cFLC. The gene discussed is CST3; the disease is cerebrovascular disorder.