CST3 and polycystic kidney disease: Other baseline characteristics significantly associated with increased risk of progression to ESRD by univariable analysis included South Asian ethnicity, a primary renal diagnosis of diabetic nephropathy or polycystic kidney disease, an age-adjusted CCI score <5, absence of malignancy, higher SBP, higher DBP, higher MAP, higher cystatin C, lower CKD-EPI eGFR, increasing urine ACR, and higher serum cFLC.