Among the 113 patients, LGMD related gene were detected in 95 patients, including 49 patients with DYSF mutations, 24 with CAPN3 mutations, seven with LMNA mutations, five with SGCA mutations, four with DES mutations, three with FKRP mutations, one with POMT1 mutations, one with TRIM32 mutations, and one with ANO5 mutations. The gene discussed is LMNA; the disease is limb-girdle muscular dystrophy.