CD47 and posterior cortical atrophy: In co-cultures, although CD47 remained unchanged under PEDF treatment, CD47 expression was reduced over time by PEDF suggesting that in PCa-macrophages co-cultures in which CD47 mRNA expression is increased, PEDF may need more time to repress CD47 mRNA or that macrophages could produce secreted or surface factor(s) inhibiting PEDF effect on CD47 (Fig 7E).