In mice, researchers have illustrated that BDNF signaling balanced dopamine-glutamate of striatal to regulate cognitive control processes.[28,29] Cognitive impairment is associated with altered synaptic plasticity and enhanced hippocampal glutaminergic expression.[30] In rats, cholinergic and neurotrophin markers, which took participate in spatial learning ability, affected cognitive decline and improvement.[31,32] We only explored association between BDNF levels and cognition, but lacked the research about the role of intermediated products in cognition. This evidence concerns the gene BDNF and Cognitive impairment.