Single-gene disorders resembling the VACTERL association have been reported and include the following: the N-Myc gene in Feingold syndrome,[10,11] the CHD7 gene in CHARGE syndrome,[12] the FANC family of genes in Fanconi anemia,[13,14] the SALL1 gene in Townes–Brocks syndrome,[15] and the GLI3 gene in Pallister–Hall syndrome.[16]. The gene discussed is GLI3; the disease is CHARGE syndrome.