PTEN and neoplasm: Loss function of PTEN was reported to up-regulation PD-L1 expression in tumor cells.[32] The structural variation frequently disrupting the 3′ region of PD-L1's open reading frame, which leads to its overexpression.[19] Interestingly, Georgiou and colleagues[20] discovered that a novel translocation juxtaposing between PD-L1 and TP63 in DLBC, and RNA-seq data also showed that the high expression of PD-L1 is accompanied with TP63 expression.