TGFB1 and neoplasm: Other mechanisms that lead to immune evasion have also been identified in lymphoma; they include the impairment of immune cell infiltration through endothelial defects, the inhibition of immune activation by the secretion of suppressive mediators such as TGF-β and IL-10 [3], the local recruitment of immunosuppressive cells such as regulatory T cells (Tregs) [4], tumor-associated macrophages (TAMs) [5] and myeloid-derived suppressor cells (MDSC) [6, 7], and the impairment of functional anti-tumor responses through the up-regulation of immune checkpoint gene expression [8–11].