Furthermore, the microscope images from the model of glioma neovasculatures established with HUVECs in three-dimensional Matrigel® demonstrated that the most significant disrupting effect on neovasculatures was after treatment with CNP-modified vinorelbine lipid vesicles, and resulted from increased cellular uptake via specific binding with NPRB (Figure 5C, 5E). This evidence concerns the gene CNP and central nervous system cancer.