AGO2 and cancer: In cell culture and mice models, these cancer exosomes contained miRNAs (miR-10b and miR-21) altered the transcriptome of recipient cells, with the RNA-induced silencing complex (RISC)-loading complex proteins (RLC), and process pre-miRNAs Dicer, TAR RNA-binding protein 2 (TRBP) and Argonaute-2 (AGO2) into mature miRNAs.