Dynamin 2 expression is significantly increased in these cancer conditions. Dynamin 2 is involved in the promotion of cytokinesis, enhancement of tumor invasion and metastasis. Dynamin 2 overexpression is associated with poor prognosis; Dynamin 2 and cortactin participate in cell migration by stabilizing F-actin bundles in filopodia. Dynamin 2 contributes to the bladder cancer invasion by controlling invadopodia formation; Mutation of dynamin 2 in oncogenesis of T-cell acute lymphoblastic leukemia. The gene discussed is DNM2; the disease is cancer.