Among the enriched biological pathways were cytokine-cytokine receptor interaction (hsa04060), ERBB signaling (hsa04012), p53 signaling (hsa04115), MAPK signaling (hsa04010), cell cycle (hsa04110), mTOR signaling (hsa04150), JAK/STAT signaling (hsa04630) and Insulin signaling (hsa04910) pathways, which were previously described as GIST-associated pathways [22]. Here, INS is linked to gastrointestinal stromal tumor.