miRNA-mRNA correlation analysis revealed a significant correlation between the all enriched miRNAs and their putative target gene KIT. Furthermore, phenotype analysis revealed miR-215-5p to be negatively correlated with the risk grade of GIST, while miR-509-3p were associated with epithelioid and mixed histological subtypes of GIST. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.