Interestingly, 7 mice injected with a high dose of STZ exhibited a significant drop in body temperature (34.8 ± 0.6 vs. 36.9 ± 0.5 °C) and were analyzed as a distinct group of STZ HD-injected mice (STZ HD Hypo) as hypothermia can impact on tau phosphorylation26. The gene discussed is MAPT; the disease is Huntington disease.