This study has demonstrated that PRKCA is involved in initiation and progression of esophageal epithelium inflammation, Barrett's esophagus, and carcinogenesis, in terms of significantly increased expression along with PLCE1 and cytokines in esophagitis, Barrett's esophagus, esophageal squamous cell carcinoma and adenocarcinoma, and in NMBA-treated rat esophageal epithelia, and it was decreased in mouse esophageal epithelia of PLCE1-deficient mouse model. The gene discussed is PLCE1; the disease is esophageal adenocarcinoma.