Through deeply mining the oncology database and determining the expression of PLCE1 and PRKCA in human esophageal biopsies, esophageal cancer tissue microarray, carcinogen NMBA-induced rat model and specific PLCE1 knockout mouse model, we have found that the expression of PLCE1 and PRKCA are elevated during esophageal inflammation development, progression and malignant transformation. Here, PRKCA is linked to esophageal cancer.