For example, cervical architecture and cervical squamous cell carcinogenesis is similar as esophagus and esophageal squamous cell carcinoma, and the upregulation of PLCE1 in high grade introepithelial neoplasm (HGN) and cervical squamous cell carcinoma (CSCC) was also similar as seen in esophageal cancer. This evidence concerns the gene PLCE1 and skin squamous cell carcinoma.