To investigate the changes of PLCE1 and PRKCA in BE and EAC, we deeply mined the Kim's Oncomine data [26] and found that both PLCE1 and PRKCA mRNA levels were dramatically increased in Barrett's Esophagus and EAC, in comparison with the non-tumor esophageal mucosa (Figure 2A and 2B). The gene discussed is PRKCA; the disease is neoplasm.