We deeply mined the data and found that in the 17 pairs of ESCC, PLCE1 mRNA levels were slightly increased, compared to the adjacent normal esophageal mucosa (p = 0.05), and PRKCA mRNA levels were dramatically elevated in ESCC (p = 0.006, Figure 1C). This evidence concerns the gene PLCE1 and esophageal squamous cell carcinoma.