This study provided further evidence that phospholipase C epsilon 1 might also be an important element that was significantly increased in Barrett's esophagus and in EAC, and genetic deletion of PLCE1 resulted in significant downregulation of the expression of some key cytokines, such as NF- κB, IL-1β, IL-6, TNFα, IFN-γ. Here, PLCE1 is linked to esophageal adenocarcinoma.