Previous studies have revealed the risk susceptibility of PLCE1 polymorphism (rs2274223) in esophageal carcinoma [20–23], we have also shown that the 5780G allele in PLCE1 is associated with esophagitis and esophageal cancer in high-risk areas of ESCC [24]. This evidence concerns the gene PLCE1 and esophageal squamous cell carcinoma.