For instance, Lee JY showed that FXR functions as oncogene since it positively correlated with lymph node metastasis, migration and invasion of pancreatic cancer [11]; while another direct evidence, obtained more recently, indicated that elevated FXR in pancreatic cancer was responsible for a less aggressiveness phenotype and favors a better prognosis [12]. Here, NR1H4 is linked to pancreatic neoplasm.