Although more patient samples need to be investigated, this suggests that FATS, a crucial inducer of p21 [8], might have a protective effect on nodal involvement during tumor development, which is confirmed by earlier reports that show a correlation between p21 expression and negative node status [20, 21] and that p21 expression alone fails to be of prognostic value [22]. This evidence concerns the gene C10orf90 and neoplasm.