For example, miR-26b up-regulates the growth hormone levels by targeting lymphoid enhancer binding factor 1 (Lef-1) in GH3 cells, whereas miR-129-5p, miR-202 and two other miRNAs repress the human growth hormone receptor (GHR) expression levels in both normal and cancer cells [17, 18]. This evidence concerns the gene LEF1 and cancer.