These data showed that LTC4 also induced the differentiation of both HT-29 and Caco-2 colon cancer cells, demonstrated through the up-regulation of two key differentiation markers, Sucrase-Isomaltase (SI) and Mucin-2, which was also observed after treatment with WNT5A in HT-29 cells [21]. The gene discussed is SI; the disease is colonic neoplasm.