Interestingly, some miR-518b target genes were previously demonstrated to associate with preeclampsia (e.g., TH and HSD3B1 for down-regulated genes, and HPX, SERPINB2, LPA and TNFSF10 for up-regulated genes)20, 21, 22, 35, 36, 37, 38 and with preeclampsia with foetal growth restriction (e.g., EDNRA, AGER, WNT2, C9, and TRPM2 for down-regulated genes, and CD69 and STC1 for up-regulated genes)23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 39. Here, HPX is linked to preeclampsia.