Likewise, among the 112 target genes up-regulated over 2-fold by the miR-518b mimic (Supplementary Table S2), four genes [hemopexin: HPX, serpin peptidase inhibitor, clade B (ovalbumin), member 2: SERPINB2, lipoprotein, Lp(a): LPA, and tumour necrosis factor superfamily, member 10: TNFSF10] show involvement in preeclampsia35, 36, 37, 38, and two genes (CD69 molecule: CD69 and stanniocalcin 1: STC1) are involved in preeclampsia with foetal growth restriction33, 34, 39 (Table 1). Here, HPX is linked to preeclampsia.