Further, a recent study demonstrated the contribution of mural cell degeneration to the progression of AD pathologies: specifically, pericyte-deficient platelet-derived growth factor receptor beta (PDGFRβ) knockout mice11, 12 crossed with transgenic mice overexpressing Swedish mutant of human amyloid precursor protein (APPsw) exhibited accelerated progression of Aβ accumulation and cognitive decline13. This evidence concerns the gene PDGFRB and Alzheimer disease.