TH and Parkinson disease: Using this PD model, our data are the first to show that acrolein is capable of inducing neurodegeneration of nigrostriatal dopaminergic system of rat brain, including acrolein-induced reductions in TH and dopamine transporter levels, decreases in TH-positive neurons in the acrolein-infused SN, depletion in striatal dopamine levels and apomorphine-induced asymmetric rotation.