PXN and triple-negative breast carcinoma: This is consistent with live cell imaging data of single GFP-paxillin expressing MDA-MB-468 (another triple negative breast carcinoma line) cells at the boundary of flat and aligned topographies demonstrating that as the cell moves into the aligned region, one can clearly observe large, non-aligned adhesions reorganize into confined, aligned adhesions as they encounter the substrate architecture (Supplementary Movie 2).