IDS and mucopolysaccharidosis type 2: Many IDS gene mutations and IDS deficiencies have been studied in human populations which result in the lysosomal storage of glycoaminoglycans and Hunter syndrome, an X-linked chromosome disease, referred to as mucopolysaccharidosis type 2 (MPS2) (Wilson et al. 1990; Rathmann et al. 1996; Chistiakov et al. 2014; Kosuga et al. 2016).