TDP-43 pathology in patients with the behavioral variant of FTLD-TDP (FTLD-TDP cases that show characteristic behavioral changes as key feature of the disease = bvFTLD-TDP) and with sporadic ALS show a characteristic pattern that suggests anatomical stages of TDP-43 pathology spreading that differed among bvFTLD-TDP and ALS [16, 18]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.