CNKSR3 and diabetic retinopathy: Like CNKSR3 which is an aldosterone receptor target gene and highly expressed in the renal cortical collecting duct and is upregulated in response to physiologic aldosterone concentrations to keep plasma volume [16], further research needed to test whether genotype GG on rs955333 could lower the expression of CNKSR3 so as to lower the prevalence of diabetic retinopathy.