HIF1A and neoplasm: Although HIF-1α is induced by these pathways known to favor tumor development and tumor progression, in more recent years a non-transcriptional function for this protein that contrasts with its canonical role has been described, whereby the protein prevents cell cycle progression by blocking DNA replication and modifying the expression of several proteins involved in cell cycle control, which results in inhibition of the G1/S transition (Goda et al., 2003; Koshiji et al., 2004; Hubbi et al., 2013).