In the context of infection, activation of this pathway is associated with an increase in proliferation via induction of β-catenin/Tcf-Lef-dependent transcription, cell survival, and cell migration, as well as enhanced protein synthesis via mTOR activation (Nagy et al., 2009; Suzuki et al., 2009; Sokolova et al., 2014). The gene discussed is MTOR; the disease is infection.