A majority of the associated diseases and predisposing risk factors for hypercoagulable states mentioned through this literature review are pregnancy, oral contraceptives, cancer/malignancies, dehydration, infections (sinusitis), thrombophilia, and other coagulopathies (Factor V Leiden, Protein C&S deficiencies, and antithrombin III deficiency) (2,7,44). This evidence concerns the gene F5 and blood coagulation disease.