Granuloma formation in giant cell arteritis (GCA), the other granulomatous large vessel vasculitis, has been clearly deciphered to involve the Th1 associated cytokines (IL-12, IFN-γ) as well as Th17 associated cytokines (IL-6, IL-17 and IL-23) [4]. The gene discussed is IFNG; the disease is Granuloma.