For example, transgenic mice with targeted LIN28B overexpression in the sympathetic adrenergic lineage, hematopoietic tissues, and intestinal epithelium caused neuroblastoma, peripheral T-cell lymphoma (PTCL), and intestinal/colon adenocarcinoma, respectively (Beachy et al., 2012; Molenaar et al., 2012; Madison et al., 2013). The gene discussed is LIN28B; the disease is neuroblastoma.